The Cadre Harmonisé (CH) is the unified tool for consensual analysis of acute food and nutrition insecurity in the Sahel and West African Region. At the regional level, the CH process is coordinated by the Permanent Inter-State Committee for Drought Control in the Sahel (CILSS), jointly managed by the Economic Community of West African States (ECOWAS) and Union Economic Monetaire of West Africa (UEMOA). The March 2022 CH analysis covered twenty-one (21) states of Nigeria and the Federal Capital Territory (FCT) using the CH Version 2.0 protocols. The analysis considered food and nutrition security outcomes (Food consumption, livelihood evolution, nutritional status and mortality); complemented with inferences drawn from the impact of relevant contributing factors (hazards and vulnerability, food availability, food access, food utilization and stability). The result of the analysis indicates that 14.5 million people (9.1%) of the analyzed population require urgent assistance in the current period (March to May, 2022). During the projected period (June to August 2022), the number of vulnerable population may rise to 19.5 million (12.3%) of the overall population analyzed, unless conscious efforts are made to provide strategic resilience-focused interventions and humanitarian assistance in areas where necessary.