The Cadre Harmonisé (CH) is the unified tool for consensual analysis of acute food and nutrition insecurity in the Sahel and West African region. At the regional level, the CH process is coordinated by the Permanent Inter-State Committee for Drought Control in the Sahel (CILSS) and jointly managed by the Economic Community of West African States (ECOWAS) and Union Economic Monetaire West Africa (UEMOA). The October, 2021 CH analysis covered twenty-one (21) states of Nigeria and the Federal Capital Territory (FCT) using the CH Version 2.0 protocols. The analysis considered food and nutrition security outcome (Food consumption, livelihood change and nutritional status); complemented with appreciation of the impact of relevant contributing factors namely, hazards and vulnerability, food availability, food access, food utilization and stability. The results of the analysis indicate that 12.9 million people (8.1% of the analysed population) require urgent assistance in the current period (Oct to Dec, 2021). During the projected period (June to August 2022), these figures may likely rise to 18.0 million people (11.3% of the overall population analysed), unless conscious efforts are made to provide strategic resilience-focused interventions as well as humanitarian assistance in areas where necessary.